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KMID : 0361020000430101062
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Korean Journal of Otolaryngology - Head and Neck Surgery
2000 Volume.43 No. 10 p.1062 ~ p.1066
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Evaluation of Proliferating Activity by Proliferating Cell Nuclear Antigen(PCNA) Expression in Human Inverted Papilloma
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이정훈/Jung Hoon Rhee
박성호/김춘길/김훈/홍영호/양훈식/Sung Ho Park/Chun Gil Kim/Hoon Kim/Young Ho Hong/Hoon Shik Yang
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Abstract
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Background and Objectives : Inverted papilloma is a rare benign tumor of nasal epithelium
associated with high recurrence rate and malignant potential. Its etiology is still uncertain, and the
mechanism of proliferation has not yet been fully described. Among the various approaches for
evaluating the proliferation activity, proliferating cell nuclear antigen (PCNA) has been introduced
as anothe marker of cellular proliferation. The purpose of this study was to detect the quantify
and compare cell proliferation in the human inverted patilloma, maxillary carcinoma, nasal polyp
and hypertrophic turbinate mucosa, and to analyze the relationship between PCNA expression and
clinicopathologic findings in human inverted papilloma.
Materials and Methods : the samples were obtained after surgical removal from 29 patients with
inverted papilloma, 5 patients with maxillary squamous cell carcinoma, 15 patients with nasal
pollyp, and 10 patients with hypertrophic turbinate. The cell proliferation was assessed by
immunohistochemical identification of the PCNA.
Results : The cell proliferation was significantly higher in the inverted papilloma and maxillary
carcinoma than in the nasal polyp and hypertrophic turbinate. The cell proliferation in the inverted
papilloma was greater when it was associated with dysplasia.
Conclusion : The increased epithelial cell proliferation seems to be involved in the development of
the inverted papilloma, and the high PCNA expression in the inverted papilloma may serve as a
useful indicator to predict the malignant transformation.
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KEYWORD
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